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Knowing the hormone receptor status of a breast cancer is important because this information can guide treatment decisions. Feb 23, - Hormone receptors are proteins — found in and on breast cells — that pick up hormone signals telling the cells to grow. A cancer is called estrogen-receptor-positive (or ER+) if it has receptors for estrogen. The cancer is progesterone-receptor-positive (PR+) if it has progesterone receptors.